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The authors did not find an association between the relief of several negative affects and smoking (also not from denicotinised cigarettes) but the relief was not dependent on nicotine intake, therefore, challenging the assumption that nicotine in smoking alleviates negative affects

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In recent years, it has been implied that TS may play a role in MS pathogenesis and that it might also affect how the disease progresses and how severe it will be (Ghasemi et al., 2017)

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